MP53-19 FEASIBILITY OF DRUG-ELUTING BIODEGRADABLE STENT FOR URETERAL STRICTURE TREATMENT IN AN ANIMAL MODEL

You have accessJournal of UrologyTrauma/Reconstruction/Diversion: Ureter (including Pyeloplasty) and Bladder Reconstruction fistula), Augmentation, Substitution, Diversion II (MP53)1 Sep 2021MP53-19 FEASIBILITY OF DRUG-ELUTING BIODEGRADABLE STENT FOR URETERAL STRICTURE TREATMENT IN AN ANIMAL MODEL Wai-Nga Chan, Dong-Ru Ho, Chih-Shou Chen, Wei-Yu Lin, Yun-Ching Huang, Jian-Hui Kuo-Tsai Yu-Liang Liu ChanWai-Nga Chan More articles by this author , HoDong-Ru Ho ChenChih-Shou Chen LinWei-Yu Lin HuangYun-Ching Huang LinJian-Hui HuangKuo-Tsai LiuYu-Liang View All Author Informationhttps://doi.org/10.1097/JU.0000000000002083.19AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Fibrosis plays an important role in ureteral stricture. The aim the present study is evaluate effectiveness histopathological sequela a rapamycin drug-eluting biodegradable stent for treatment stricture using rabbit model. METHODS: Dose dependent effect on ureter component cell lines are tested. Fibrogenic signaling proteins, including a-SMA Smad was evaluated with or without TGF-b co-treatment. Upper fibrosis induced open surgery thermal injury male rabbits. Biodegradable stents, drug eluting, were inserted. Gross anatomy changes, along collagen deposition Masson’s trichrome stain. Smad, a-SMA, SNAI 1 expressions checked immunohistochemistry Western blotting 4 weeks after operation. RESULTS: COL3A1 major subtype depositing healing process. Its decreased groups stents. Rapamycin-eluting can affect EMT pathway significantly modifying expression, respectively. Hydronephrosis severe thermally injured Once stents place effective, only pelvicectasis would be found. However, gross histopathology remained similar between stented drug-eluting, but they different compared sham operated controls. CONCLUSIONS: Intralumenal administration implanting bioresorbable scaffold may modify associated pathway. mTOR inhibitor, applying other effective chemicals, promising way prevent injury. Source Funding: This work supported grants from Chang Gung Medical Foundation, Grant Number CMRPG6C0313, CMRPG6G0381, CMRPG6H0551 © 2021 American Urological Association Education Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e946-e947 Advertisement Copyright & Permissions© Inc.MetricsAuthor Information Expand Loading ...